KIN-281 |CAS:74151-26-1 Probechem Biochemicals

Chemical Structure : KIN-281

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KIN-281 (KIN281)

货号: PC-61630Not For Human Use, Lab Use Only.

KIN-281 is a small molecule that inhibits multiple kinases including MELK and the non-receptor tyrosine kinase BMX with IC50 of 1.4 and 1.9 uM, respectively.

规格	价格	库存	数量
25 mg		Get quote
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200 mg		Get quote
1 g		Get quote

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生物&药学活性

KIN-281 is a small molecule that inhibits multiple kinases including MELK and the non-receptor tyrosine kinase BMX with IC50 of 1.4 and 1.9 uM, respectively.
KIN281 also inhibits BLK, CAMK Iiγ/δ, CAMK Iα, Tie2, BTK with IC50 of 1-10 uM.
KIN281 inhibit STAT3 activation, autophagy and cancer cell anchorage-independent growth in MDA-MB-231 and MDA-MB-468 breast cancer cells.

物理化学性质&存储条件

分子量	506.9
分子式	C25H30Cl3N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N4-(5-(diethylamino)pentan-2-yl)-2-(2,4,6-trichlorostyryl)quinazoline-4,6-diamine

参考文献

1. Zhou D, et al. Bioorg Med Chem. 2017 Jun 15;25(12):2995-3005.

KIN-281 (KIN281)

生物&药学活性

物理化学性质&存储条件

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KIN-281 (KIN281)

生物&药学活性

物理化学性质&存储条件

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