KIF18A inhibitor 24

Chemical Structure : KIF18A inhibitor 24

CAS No.: 2600577-49-7

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货号: PC-72268Not For Human Use, Lab Use Only.

KIF18A inhibitor 24 is a highly potent, in vivo active inhibitor of mitotic kinesin KIF18A with IC50 of 61 nM.

规格	价格	库存
1 mg	￥2480	In stock
5 mg	￥4980	In stock
10 mg		Get quote
25 mg		Get quote

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生物&药学活性

KIF18A inhibitor 24 is a highly potent, in vivo active inhibitor of mitotic kinesin KIF18A with IC50 of 61 nM.
KIF18A inhibitor 24 binds at the interface of KIF18A and tubulin.
KIF18A inhibitor 24 exhibits significant mitotic arrest in MDA-MB-157 mitotic cells with EC50 of 11 nM, followed by cell death either in mitosis or in the subsequent interphase, which is sustained for 24 h.

物理化学性质&存储条件

分子量	574.755
分子式	C28H38N4O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(N-(tert-butyl)sulfamoyl)phenyl)-4-((1-methylcyclopropane)-1-sulfonamido)-2-(6-azaspiro[2.5]octan-6-yl)benzamide

参考文献

1. Nuria A Tamayo, et al. J Med Chem. 2022 Mar 24;65(6):4972-4990.