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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-STAT-KI16
KI16

Chemical Structure : KI16

CAS No.: 1090696-43-7

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KI16 (STAT3 inhibitor KI16)

货号: PC-63206Not For Human Use, Lab Use Only.

KI16 is a novel small molecules that inhibit STAT3-dependent transcription and function, interacts with the STAT3 SH2 domain.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    KI16 is a novel small molecules that inhibit STAT3-dependent transcription and function, interacts with the STAT3 SH2 domain.
    KI16 inhibits STAT3 phosphorylation and transcriptional activity in response to IL6 stimulation.
    KI16 inhibits cell viability preferentially in STAT3-dependent cell lines.

    物理化学性质&存储条件

    分子量 328.302
    分子式 C14H8N4O4S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-nitro-2-((3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)thio)nicotinonitrile

    参考文献

    1. Kolosenko I, et al. PLoS One. 2017 Jun 21;12(6):e0178844.

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