KI-T28-03

Chemical Structure : KI-T28-03

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货号: PC-27364Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

KI-T28-03 is a selective small-molecule TRIM28 inhibitor that binds the TRIM28 PHD-bromodomain with ITC KD of 5 uM for full-length human TRIM28 protein, impairs leukemia cell proliferation and drives myeloid differentiation.
KI-T28-03 stabilizes wild-type TRIM28 but destabilizes the F772A mutant, confirming that F772 is required for productive compound engagement.
KI-T28-03 disrupts TRIM28-dependent programs without globally displacing it from chromatin.
KI-T28-03 inhibits viability of human MOLM13 leukemia cells with IC50 of 4.85 uM.
KI-T28-03 phenocopies key features of genetic TRIM28 loss and selectively impairs leukemia cell fitness.

物理化学性质&存储条件

分子量	380.87
分子式	C19H25ClN2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-acetyl-4-(4-butoxy-3-chloro-5-ethoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one

参考文献

1. Amos SM, et al. bioRxiv [Preprint]. 2026 Jul 10:2026.07.08.737260.

KI-T28-03

生物&药学活性

物理化学性质&存储条件

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KI-T28-03

生物&药学活性

物理化学性质&存储条件

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