KI-301670 | NUAK1 inhibitor | Probechem Biochemicals

Chemical Structure : KI-301670

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KI-301670 (KI301670)

货号: PC-47031Not For Human Use, Lab Use Only.

KI-301670 is a novel potent, specific NUAK1 inhibitor, disturbs NUAK1 signaling by targeting its ATP binding site, effectively inhibits the PI3K/AKT pathway in pancreatic cancer cells.

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生物&药学活性

KI-301670 is a novel potent, specific NUAK1 inhibitor, disturbs NUAK1 signaling by targeting its ATP binding site, effectively inhibits the PI3K/AKT pathway in pancreatic cancer cells.
KI-301670 effectively inhibited pancreatic cancer growth and proliferation, and induced cell cycle arrest, markedly G0/G1 arrest, by increasing the expression of p27 and decreasing expression of p-Rb and E2F1.
KI-301670 effectively inhibited the growth of pancreatic cancer cells in a dose-dependent manner (IC50, 1.7 uM, MIA PaCa-2 and 2.6 uM for AsPC-1 cells).
KI-301670 significantly increased the expression levels of cleaved PARP and decreased the expression of Mcl-1, survivin, and XIAP in pancreatic cancer cells.
KI-301670 (30 mg/kg) inhibited tumor growth in mouse pancreatic cancer xenograft model.

物理化学性质&存储条件

分子量	451.494
分子式	C22H28F3N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-N4-((tetrahydrofuran-2-yl)methyl)-5-(trifluoromethyl)pyrimidine-2,4-diamine

参考文献

1. Seo MS, et al. Biomed Pharmacother. 2022 Aug;152:113241.

KI-301670 (KI301670)

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物理化学性质&存储条件

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KI-301670 (KI301670)

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