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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-AMPK-KHKI-01215
KHKI-01215

Chemical Structure : KHKI-01215

CAS No.:

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KHKI-01215 (KHKI 01215)

货号: PC-22623Not For Human Use, Lab Use Only.

KHKI-01215 is a highly potent NUAK family kinase 2 (NUAK2) inhibitor with IC50 of 52 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

KHKI-01215 is a highly potent NUAK family kinase 2 (NUAK2) inhibitor with IC50 of 52 nM.
KHKI-01128 suppresses cell proliferation IC50 of 3.16 μM, and induces apoptosis of SW480 cells.
KHKI-01128 effectively suppresses the expression of YES1-associated transcriptional regulator (YAP) target genes.

物理化学性质&存储条件

分子量 598.41
分子式 C24H26F3IN6O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(3-(dimethylamino)phenoxy)-5-iodo-N-(4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)pyrimidin-2-amine

参考文献

1. Seung Hyeong Lee, et al. Anticancer Res. 2024 Jul;44(7):2909-2919.

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