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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-AMPK-KHKI-01128
KHKI-01128

Chemical Structure : KHKI-01128

CAS No.:

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KHKI-01128 (KHKI 01128)

货号: PC-22622Not For Human Use, Lab Use Only.

KHKI-01128 is a highly potent NUAK family kinase 2 (NUAK2) inhibitor with IC50 of 24 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    KHKI-01128 is a highly potent NUAK family kinase 2 (NUAK2) inhibitor with IC50 of 24 nM.
    KHKI-01128 suppresses cell proliferation IC50 of 1.26 μM, and induces apoptosis of SW480 cells.
    KHKI-01128 effectively suppresses the expression of YES1-associated transcriptional regulator (YAP) target genes.

    物理化学性质&存储条件

    分子量 582.63
    分子式 C29H33F3N8O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(2-methoxy-4-(4-methylpiperazin-1-yl)phenoxy)-2-((4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)amino)pyrimidine-5-carbonitrile

    参考文献

    1. Seung Hyeong Lee, et al. Anticancer Res. 2024 Jul;44(7):2909-2919.

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