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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Adenylate Cyclase-KH7
KH7

Chemical Structure : KH7

CAS No.: 330676-02-3

KH7 (sAC inhibitor KH7)

货号: PC-60892Not For Human Use, Lab Use Only.

KH7 is a potent, specific soluble adenylyl cyclase (sAC) inhibitor that inhibits Mn2+-dependent sAC with IC50 of 2.7 uM.

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5 mg ¥1580 In stock
10 mg ¥2480 In stock
25 mg ¥3980 In stock
50 mg ¥5880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

KH7 is a potent, specific soluble adenylyl cyclase (sAC) inhibitor that inhibits Mn2+-dependent sAC with IC50 of 2.7 uM.
KH7 inhibits physiologically stimulated sAC with similar potency with IC50 of 8.0 uM.
KH7 completely blocks the capacitation-induced rise in cAMP in wild-type sperm at 10 uM, inhibits in vitro fertilization.

物理化学性质&存储条件

分子量 419.297
分子式 C17H15BrN4O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(E)-2-((1H-benzo[d]imidazol-2-yl)thio)-N'-(5-bromo-2-hydroxybenzylidene)propanehydrazide

参考文献

1. Bitterman JL, et al. J Pharmacol Exp Ther. 2013 Dec;347(3):589-98.

2. Hess KC, et al. Dev Cell. 2005 Aug;9(2):249-59.

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