KH-CB19 |CAS:1354037-26-5 Probechem Biochemicals

Chemical Structure : KH-CB19

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KH-CB19 (KH-CB-19)

货号: PC-43237Not For Human Use, Lab Use Only.

KH-CB19 is a potent and highly specific inhibitor of CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4) with IC50 of 20 nM (CLK1), displays almost 100-fold selectivity against the CLK3 isoform.

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生物&药学活性

KH-CB19 is a potent and highly specific inhibitor of CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4) with IC50 of 20 nM (CLK1), displays almost 100-fold selectivity against the CLK3 isoform.
KH-CB19 effectively suppresses phosphorylation of SR (serine/arginine) proteins SRp75 and SRp55 in cells.
KH-CB19 significantly reduces the basal expression of flTF as well as asHTF, also lowers TNF-α-induced expression of both TF mRNA splice variants to baseline in HMEC-1 cells.

物理化学性质&存储条件

分子量	338.1886
分子式	C15H13Cl2N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Indole-2-carboxylic acid, 3-[(1E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-, ethyl ester

参考文献

1. Fedorov O, et al. Chem Biol. 2011 Jan 28;18(1):67-76.

KH-CB19 (KH-CB-19)

生物&药学活性

物理化学性质&存储条件

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KH-CB19 (KH-CB-19)

生物&药学活性

物理化学性质&存储条件

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