KH-176 |CAS:1541170-75-5 Probechem Biochemicals

Chemical Structure : KH-176

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KH-176 (Sonlicromanol;KH176)

货号: PC-36101Not For Human Use, Lab Use Only.

KH-176 (KH176, Sonlicromanol) is a smal molecule ROS-redox modulator, effectively reduces increased cellular ROS levels and protects OXPHOS deficient primary cells against redox perturbation by targeting the Thioredoxin/Peroxiredoxin system.

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生物&药学活性

KH-176 (KH176, Sonlicromanol) is a smal molecule ROS-redox modulator, effectively reduces increased cellular ROS levels and protects OXPHOS deficient primary cells against redox perturbation by targeting the Thioredoxin/Peroxiredoxin system.
KH-176 significantly improves rotarod and gait performance and reduces the degeneration of retinal ganglion cells in Ndufs4 -/- mice.
KH-176 shows therapeutic effects in mammalian model of Leigh Disease.

物理化学性质&存储条件

分子量	332.444
分子式	C19H28N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S)-6-hydroxy-2,5,7,8-tetramethyl-N-[(3R)-piperidin-3-yl]-3,4-dihydro-2H-1-benzopyran-2-carboxamide

参考文献

1. de Haas R, et al. Sci Rep. 2017 Sep 15;7(1):11733.

2. Koene S, et al. Orphanet J Rare Dis. 2017 Oct 16;12(1):163.

3. Beyrath J, et al. Sci Rep. 2018 Apr 26;8(1):6577.

KH-176 (Sonlicromanol;KH176)

生物&药学活性

物理化学性质&存储条件

参考文献

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KH-176 (Sonlicromanol;KH176)

生物&药学活性

物理化学性质&存储条件

参考文献

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