欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Microtubule/Tubulin-KGP591
KGP591

Chemical Structure : KGP591

CAS No.:

加入收藏

KGP591 (KGP 591, KGP-591)

货号: PC-21387Not For Human Use, Lab Use Only.

KGP591 is a small molecule inhibitor of tubulin polymerization with IC50 of 0.57 uM, exhibits cytotoxicity against the MCF-7 and MDA-MB-231 human breast cancer cell lines with GI50 of 320 and 102 nM, respectively.

规格 价格 库存 数量
50 mg Get quote
100 mg Get quote
200 mg Get quote
1 g Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

KGP591 is a small molecule inhibitor of tubulin polymerization with IC50 of 0.57 uM, exhibits cytotoxicity against the MCF-7 and MDA-MB-231 human breast cancer cell lines with GI50 of 320 and 102 nM, respectively.
KGP594 at 0.5 μM demonstrates 51% inhibition of colchicine binding.
KGP591 (200 nM) treatment results in G2/M cell cycle arrest of MDA-MB-231 cells.
KGP591 disrupts microtubule structure and cell morphology in MDA-MB-231 cells, and demonstrates significant inhibition of MDA-MB-231 cell migration in a wound healing (scratch) assay.

物理化学性质&存储条件

分子量 403.43
分子式 C24H21NO5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(6-(3-hydroxyphenyl)-1H-indol-3-yl)(3,4,5-trimethoxyphenyl)methanone

参考文献

1. Ren W, et al. Eur J Med Chem. 2023 Sep 6;263:115794.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: