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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-SGLT-KGA-2727
KGA-2727

Chemical Structure : KGA-2727

CAS No.: 666842-36-0

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KGA-2727 (KGA2727)

货号: PC-63375Not For Human Use, Lab Use Only.

KGA-2727 is a potent, selective SGLT1 inhibitor with Ki of 97.4 nM, >100-fold selectivity over SGLT2.

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5 mg ￥2480 In stock
10 mg ￥3880 In stock
25 mg ￥5980 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

KGA-2727 is a potent, selective SGLT1 inhibitor with Ki of 97.4 nM, >100-fold selectivity over SGLT2.
KGA-2727 attenuates the elevation of plasma glucose after glucose loading in streptozotocin-induced diabetic rats, preserves glucose-stimulated insulin secretion and reduces urinary glucose excretion with improved morphological changes of pancreatic islets and renal distal tubules in ZDF rats.

物理化学性质&存储条件

分子量 536.626
分子式 C26H40N4O8
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-((3-(4-((5-isopropyl-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1H-pyrazol-4-yl)methyl)-3-methylphenoxy)propyl)amino)propanamide

参考文献

1. Shibazaki T, et al. J Pharmacol Exp Ther. 2012 Aug;342(2):288-96.

2. Dobbins RL, et al. Am J Physiol Gastrointest Liver Physiol. 2015 Jun 1;308(11):G946-54.

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