KG-501 |CAS:18228-17-6 Probechem Biochemicals

Chemical Structure : KG-501

CAS No.: 18228-17-6

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KG-501 (Naphthol AS-E phosphate )

货号: PC-70246Not For Human Use, Lab Use Only.

A small-molecule antagonist of CREB-CBP interaction, inhibits the cAMP-dependent activation of cellular genes via CREB.

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25 mg	￥880	In stock
50 mg	￥1280	In stock
100 mg	￥1780	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

KG-501 (Naphthol AS-E phosphate) is a small-molecule antagonist of CREB-CBP interaction, inhibits the cAMP-dependent activation of cellular genes via CREB.
KG-501 (Naphthol AS-E phosphate) disruptes phospho (Ser-133) CREB binding to CBP KIX domain with Ki of 90 uM, similar Ki for binding of phospho (Ser-133) CREB protein to p300.
KG-501 (Naphthol AS-E phosphate) also interferes with the Myb-KIX interaction in vitro and inhibits Myb activity in vivo.

物理化学性质&存储条件

分子量	377.72
分子式	C17H13ClNO5P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Naphthanilide, 4'-chloro-3-hydroxy-, phosphate (6CI,7CI)

参考文献

1. Best JL, et al. Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17622-7.

2. Uttarkar S, et al. Mol Cancer Ther. 2015 Jun;14(6):1276-85.

3. van der Sligte NE, et al. Oncotarget. 2015 Jun 20;6(17):14970-81.

KG-501 (Naphthol AS-E phosphate )

生物&药学活性

物理化学性质&存储条件

参考文献

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KG-501 (Naphthol AS-E phosphate )

生物&药学活性

物理化学性质&存储条件

参考文献

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