KFP-H008

Chemical Structure : KFP-H008

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货号: PC-27265Not For Human Use, Lab Use Only.

KFP-H008 is a potent potassium-competitive acid blocker (P-CAB), exhibits inhibitory activities against H+-K+-ATPase with IC50 of 29 nM (pH 6.5 condition), does not affect Na+-K+-ATPase activity

规格	价格	库存	数量
25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

KFP-H008 is a potent potassium-competitive acid blocker (P-CAB), exhibits inhibitory activities against H+-K+-ATPase with IC50 of 29 nM (pH 6.5 condition), does not affect Na+-K+-ATPase activity
KFP-H008 inhibits basal acid secretion, 2-deoxy-D-glucose- (2DG-) stimulated gastric acid secretion in rats.
KFP-H008 blocked histamine-stimulated acid secretion in rats and heidenhain pouch dogs and reversed acid output in isolated gastric perfusion under histamine stimulation.
KFP-H008 inhibits H+-K+-ATPase activity both at pH 6.5 and pH 7.5, and is unaffected by pH, inhibits H+-K+-ATPase activity in a K+-competitive manner with Ki of 4 nM.

物理化学性质&存储条件

分子量	366.44
分子式	C19H18N4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(5-(1H-indol-5-yl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine

参考文献

1. Cheng-Yuan Li, et al. Eur J Pharmacol. 2017 Sep 5:810:112-119.

KFP-H008

生物&药学活性

物理化学性质&存储条件

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KFP-H008

生物&药学活性

物理化学性质&存储条件

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