KF26777 | A3 adenosine antagonist | Probechem Biochemicals

Chemical Structure : KF26777

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KF26777 (KF-26777)

货号: PC-20639Not For Human Use, Lab Use Only.

KF-26777 (KF26777) is a potent and selective adenosine A3 receptor antagonist with Ki of 0.2 nM (human A3 receptor).

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生物&药学活性

KF-26777 (KF26777) is a potent and selective adenosine A3 receptor antagonist with Ki of 0.2 nM (human A3 receptor).
KF-26777 displays 9000-, 2350- and 3100-fold selectivity vs. human adenosine A(1), A(2A) and A(2B) receptors, respectively.
KF26777 inhibits the binding of [35S]GTPgammaS stimulated by 1 microM 2-Cl-IB-MECA in competitive binding assays (IC50=250 nM).
KF26777 antagonizes [Ca(2+)](i) mobilization induced by Cl-IB-MECA with K(B) value of 0.42 nM.

物理化学性质&存储条件

分子量	374.24
分子式	C16H16BrN5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-bromophenyl)-4-propyl-1,4,7,8-tetrahydro-5H-imidazo[2,1-i]purin-5-one

参考文献

1. Saki M, et al. Eur J Pharmacol. 2002 May 31;444(3):133-41.

2. Yamano K, et al. Biochem Pharmacol. 2005 Nov 15;70(10):1487-96.

KF26777 (KF-26777)

生物&药学活性

物理化学性质&存储条件

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KF26777 (KF-26777)

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物理化学性质&存储条件

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