Chemical Structure : KDM5-C49 hydrochloride
CAS No.: 3026728-26-4
货号: PC-26560Not For Human Use, Lab Use Only.
KDM5-C49 hydrochloride is a potent, selective KDM5 inhibitor with IC50 of 25, 30 and 59 nM for KDM5A, B and C, respectively.
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KDM5-C49 hydrochloride is a potent, selective KDM5 inhibitor with IC50 of 25, 30 and 59 nM for KDM5A, B and C, respectively.
KDM5-C49 displays 25-100-fold selectivity over KDM6B, 2-30-fold selectivity over KDM4 family, but with less cell-permeablity.
| 分子量 | 344.84 | |
| 分子式 | C15H25ClN4O3 | |
| 外观性状 | Solid | |
| 储存条件 |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinic acid hydrochloride |
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1. Johansson C, et. Nat Chem Biol. 2016 Jul;12(7):539-45.
2. Horton JR, et al. Cell Chem Biol. 2016 Jul 21;23(7):769-81.
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