KDM2A inhibitor 183c

Chemical Structure : KDM2A inhibitor 183c

加入收藏

货号: PC-27206Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

KDM2A inhibitor 183c is a potent inhibitor of histone lysine-specific demethylase 2A (KDM2A, FBXL11 or JHDM1A) with high activity against KDM2A (IC50=11 nM), KDM2B (IC50=13 nM) and KDM7A (IC50=9.6 nM) in vitro.
183c shows no activity against KDM5C, KDM3A and KDM6A.
183c occupies the H3K36me2 substrate pocket, with a crucial group mimicking dimethylated lysine 36.
183c selectively sensitive against several ALT-positive cell lines (SAOS2 cell IC50=3 nM).

物理化学性质&存储条件

分子量	390.53
分子式	C25H30N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(6-((3R,4R)-1-cyclobutyl-4-ethylpiperidine-3-carbonyl)-2-methoxynaphthalen-1-yl)acetonitrile

参考文献

1. Mader P, et al. Commun Chem. 2026 Jun 27. doi: 10.1038/s42004-026-02100-9.

2. Patent WO2016112284A1.