KDM1A inhibitor JH-1

Chemical Structure : KDM1A inhibitor JH-1

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货号: PC-28784Not For Human Use, Lab Use Only.

KDM1A inhibitor JH-1 is a highly potent, selective Lysine-specific demethylase 1 (KDM1A, LSD1) inhibitor with IC50 of 35 nM, JH-1 selectively binds KDM1A and inhibits H3K4me1/2 demethylation, induces both ferroptosis (lipid ROS accumulation) and apoptosis in esophageal cancer cells.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

KDM1A inhibitor JH-1 is a highly potent, selective Lysine-specific demethylase 1 (KDM1A, LSD1) inhibitor with IC50 of 35 nM, JH-1 selectively binds KDM1A and inhibits H3K4me1/2 demethylation, induces both ferroptosis (lipid ROS accumulation) and apoptosis in esophageal cancer cells.

物理化学性质&存储条件

分子量	384.48
分子式	C24H24N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-((4-(Diethylamino)phenyl)amino)quinazolin-7-yl)phenol

参考文献

1. Zhao LJ, et al. J Med Chem. 2026 Nov 12;69(21):25340-25360.