KD5170 | Class I /II HDAC inhibitor | Probechem Biochemicals

Chemical Structure : KD5170

CAS No.: 940943-37-3

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KD5170 (KD 5170, KD-5170)

货号: PC-21042Not For Human Use, Lab Use Only.

KD5170 (KD-5170) is a potent mercaptoketone-based Class I and II-histone deacetylase (HDAC) inhibitor with IC50 of 45 nM in HeLa cell-based histone H3 hyperacetylation assay.

规格	价格	库存
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg	￥4980	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

KD5170 (KD-5170) is a potent mercaptoketone-based Class I and II-histone deacetylase (HDAC) inhibitor with IC50 of 45 nM in HeLa cell-based histone H3 hyperacetylation assay.
KD5170 displays cytotoxic activities of KD5170 against cell lines from the NCI-60 panel with micromolar to submicromolar potency.
KD5170 (30 mg/kg oral dose) increases tumor H3 hyperacetylation in vivo.
KD5170 (42 and 84 mg/kg) exhibits significant tumor growth inhibition in HCT-116 tumor bearing nude mice.

物理化学性质&存储条件

分子量	451.56
分子式	C20H25N3O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	S-(2-(6-((4-(3-(dimethylamino)propoxy)phenyl)sulfonamido)pyridin-3-yl)-2-oxoethyl) ethanethioate

参考文献

1. Payne JE, et al. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6093-6.

2. Feng R,et al. Mol Cancer Ther. 2008 Jun;7(6):1494-505.

3. Hassig CA, et al.Mol Cancer Ther. 2008 May;7(5):1054-65.

KD5170 (KD 5170, KD-5170)

生物&药学活性

物理化学性质&存储条件

参考文献

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KD5170 (KD 5170, KD-5170)

生物&药学活性

物理化学性质&存储条件

参考文献

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