KCN1 | HIF-1 inhibitor | Probechem Biochemicals

Chemical Structure : KCN1

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KCN1 (HIF inhibitor KCN1)

货号: PC-35912Not For Human Use, Lab Use Only.

KCN1 (HIF inhibitor KCN1) is a small molecule inhibitor of the HIF-1 pathway, antagonizes HIF transcription in bioassay, blocks the p300/HIF-1α interaction, and exert potent anticancer activity in vitro and in vivo.

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生物&药学活性

KCN1 (HIF inhibitor KCN1) is a small molecule inhibitor of the HIF-1 pathway, antagonizes HIF transcription in bioassay, blocks the p300/HIF-1α interaction, and exert potent anticancer activity in vitro and in vivo.
KCN1 specifically inhibits HIF reporter gene activity in several glioma cell lines at the nanomolar leve, also downregulates transcription of endogenous HIF-1 target genes, such as VEGF, Glut-1, and carbonic anhydrase 9, in a hypoxia-responsive element (HRE)-dependent manner.
KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1α interaction with cofactors p300/CBP.

物理化学性质&存储条件

分子量	465.56
分子式	C26H27NO5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-N-phenylbenzenesulfonamide

参考文献

1. Yin S, et al. Clin Cancer Res. 2012 Dec 15;18(24):6623-33.

2. Shi Q, et al. ACS Med Chem Lett. 2012 Jun 21;3(8):620-5.

3. Wang W, et al. PLoS One. 2012;7(9):e44883.

KCN1 (HIF inhibitor KCN1)

生物&药学活性

物理化学性质&存储条件

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KCN1 (HIF inhibitor KCN1)

生物&药学活性

物理化学性质&存储条件

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