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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-KCC-07
KCC-07

Chemical Structure : KCC-07

CAS No.: 315702-75-1

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KCC-07 (KCC07)

货号: PC-25505Not For Human Use, Lab Use Only.

KCC-07 is a potent, selective and BBB-penetrable inhibitor of MBD2 (methyl CpG binding domain protein 2), prevents binding of MBD2 to methylated DNA, reactivates ADGRB1 expression and prevents MDM2-mediated p53 polyubiquitination.

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5 mg ￥580 In stock
10 mg ￥880 In stock
25 mg ￥1480 In stock
50 mg ￥2480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

KCC-07 is a potent, selective and BBB-penetrable inhibitor of MBD2 (methyl CpG binding domain protein 2), prevents binding of MBD2 to methylated DNA, reactivates ADGRB1 expression and prevents MDM2-mediated p53 polyubiquitination.
KCC-07 abrogated MBD2 binding to the ADGRB1 promoter and restored BAI1 mRNA and protein expression in BAI1-silent MB cells.
KCC-07 inhibited MB cell growth in vitro, with induction of anti-proliferative BAI1/p53/p21 signaling.
KCC-07 (100 mg/kg i.p.; 5 days/week) inhibited MB growth in vivo by reactivating the BAI1-p53 tumor suppressor axis.

物理化学性质&存储条件

分子量 269.32
分子式 C14H11N3OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-((4-(Pyridin-2-yl)thiazol-2-yl)amino)phenol

参考文献

1. Lee D, et al. Exp Neurobiol. 2025 Aug 31;34(4):138-146.

2. Peng B, et al. Ann Med. 2025 Dec;57(1):2458207.

3. Dan Zhu, et al. Cancer Cell. 2018 Jun 11;33(6):1004-1016.e5.

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