KCB-F06

Chemical Structure : KCB-F06

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货号: PC-22794Not For Human Use, Lab Use Only.

KCB-F06 is a small molecule Keap1-Nrf2 PPI inhibitor, inhibits RANKL-induced osteoclastogenesis in vitro and blocks OVX-mouse bone loss in vivo.

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生物&药学活性

KCB-F06 is a small molecule Keap1-Nrf2 PPI inhibitor, inhibits RANKL-induced osteoclastogenesis in vitro and blocks OVX-mouse bone loss in vivo.
KCB-F06 enhances the expression of Nrf2 and subsequent inhibition of osteoclastogenesis.
KCB-F06 can block osteoclastogenesis by activating Nrf2-mediated oxidative stress response.
KCB-F06 suppresses the RANKL-induced phosphorylation of I-κB and p65 NF-kB in pre-osteoclasts.
KCB-F06 inhibits osteoclast-specific gene expression during RANKL-induced osteoclastogenesis.

物理化学性质&存储条件

分子量	454.60
分子式	C24H26N2O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[2-methyl-4-(phenylsulfanylmethyl)phenyl]-2-(N-methylsulfonylanilino)propanamide

参考文献

1. Chen Z, et al. Antioxidants (Basel). 2024 Jul 15;13(7):850.

KCB-F06

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物理化学性质&存储条件

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KCB-F06

生物&药学活性

物理化学性质&存储条件

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