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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Heat Shock Protein (HSP)-KBU2046
KBU2046

Chemical Structure : KBU2046

CAS No.: 1143863-69-7

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KBU2046 (KBU 2046, KBU-2046)

货号: PC-35293Not For Human Use, Lab Use Only.

KBU2046 (KBU-2046) is a highly selective inhibitor of metastasis, binds to and stabilizes CDC37/HSP90β heterocomplexes.

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10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

KBU2046 (KBU-2046) is a highly selective inhibitor of metastasis, binds to and stabilizes CDC37/HSP90β heterocomplexes.
KBU2046 selectively disrupts heterocomplex function and inhibits cancer cell motility, only binds to HSP90β and CDC37 when both proteins are present, does not bind to either protein alone.
KBU2046 decreases phosphorylation of HSP90β, inhibits cancer metastasis and prolongs life in vivo.
KBU2046-mediated changes in the signature of client proteins bound to the HSP90β/CDC37 heterocomplex mediate effects upon cell motility.

物理化学性质&存储条件

分子量 242.249
分子式 C15H11FO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(4-fluorophenyl)chroman-4-one

参考文献

1. Xu L, et al. Nat Commun. 2018 Jun 22;9(1):2454.

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