KB SRC 4 |CAS:1380088-03-8 Probechem Biochemicals

Chemical Structure : KB SRC 4

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KB SRC 4 (c-Src-IN-4)

货号: PC-62865Not For Human Use, Lab Use Only.

KB SRC 4 (c-Src-IN-4) is a potent, highly selective c-Src kinase inhibitor with Ki of 44 nM, does not inhibit c-Abl up to 125 uM, and binds to c-Src-TM (Q275G, C277Q, F278Y) with similar potency to that of wild-type c-Src.

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生物&药学活性

KB SRC 4 (c-Src-IN-4) is a potent, highly selective c-Src kinase inhibitor with Ki of 44 nM, does not inhibit c-Abl up to 125 uM, and binds to c-Src-TM (Q275G, C277Q, F278Y) with similar potency to that of wild-type c-Src.
KB SRC 4 significantly more efficacious than multi-kinase inhibition in cell culture.

物理化学性质&存储条件

分子量	555.042
分子式	C32H23ClN8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-(1-([1,1'-biphenyl]-3-ylmethyl)-1H-1,2,3-triazol-5-yl)phenyl)-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

参考文献

1. Brandvold KR, et al. ACS Chem Biol. 2012 Aug 17;7(8):1393-8.

KB SRC 4 (c-Src-IN-4)

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物理化学性质&存储条件

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KB SRC 4 (c-Src-IN-4)

生物&药学活性

物理化学性质&存储条件

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