KBP-7018 |CAS:1613437-66-3 Probechem Biochemicals

Chemical Structure : KBP-7018

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KBP-7018 (KBP 7018, KBP7018)

货号: PC-60151Not For Human Use, Lab Use Only.

KBP-7018 is a potent, multikinase inhibitor with IC50 of 10, 7.6 and 25 nM for c-Kit, RET and PDGFRβ, respectively.

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生物&药学活性

KBP-7018 is a potent, multikinase inhibitor with IC50 of 10, 7.6 and 25 nM for c-Kit, RET and PDGFRβ, respectively.
KBP-7018 also potently inhibits FLT3, VEGFR2, Fyn, PDGFRα and VEGFR2.
KBP-7018 shows promising outcomes for the treatments of idiopathic pulmonary fibrosis (IPF).

物理化学性质&存储条件

分子量	538.604
分子式	C31H30N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methyl (Z)-3-(((1-(2-morpholinoacetyl)indolin-5-yl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate

参考文献

1. Huang Z, et al. ACS Med Chem Lett. 2017 Sep 30;8(11):1142-1147.

2. Huang Z, et al. Drug Des Devel Ther. 2015 Aug 5;9:4319-28.

KBP-7018 (KBP 7018, KBP7018)

生物&药学活性

物理化学性质&存储条件

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KBP-7018 (KBP 7018, KBP7018)

生物&药学活性

物理化学性质&存储条件

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