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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-p97/VCP-KB3409
KB3409

Chemical Structure : KB3409

CAS No.:

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KB3409 (KB-3409)

货号: PC-27881Not For Human Use, Lab Use Only.

KB3409 is an allosteric activator of valosin-containing protein (VCP/p97), directly binds VCP and reticulocalbin-2 (RCN2), enhancing VCP ATPase activity and promoting autophagic flux.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

KB3409 is an allosteric activator of valosin-containing protein (VCP/p97), directly binds VCP and reticulocalbin-2 (RCN2), enhancing VCP ATPase activity and promoting autophagic flux.
KB3409 (1 uM) significantly reduced the ROS levels in senescent fibroblasts.
KB3409 interacts with VCP and RCN2.
KB3409 significantly reduces RCN2 mRNA expression in senescent fibroblasts, significantly increases VCP mRNA expression.
KB3409 directly accelerates VCP ATPase activity through an allosteric mechanism of action.
KB3409 promotes mitochondrial quality control by enhancing VCP-associated autophagic flux.
KB3409 decreases mitochondrial Ca2+ overload via RCN2, significantly suppresses mPTP opening in shCTRL-transduced senescent fibroblasts.
KB3409 enhances mitochondrial respiratory capacity, restores mitochondrial function, reduces ROS levels, and functionally reverses cellular senescence phenotypes.

物理化学性质&存储条件

分子量 390.36
分子式 C20H17F3N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

ethyl 5-(2-methoxyphenyl)-1-(4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carboxylate

参考文献

1. Lee YJ, et al. Antioxidants (Basel). 2026 Aug 13;15(8):1006.

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