KB-R7943 | NCX3 inhibitor | Probechem Biochemicals

Chemical Structure : KB-R7943

CAS No.: 182004-65-5

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KB-R7943 (No.7943, KB-R7943 mesylate)

货号: PC-73274Not For Human Use, Lab Use Only.

KB-R7943 (No.7943) is a selective inhibitor of Na+/Ca2+ exchanger (NCX), 3-fold more inhibitory to NCX3 than to NCX1 or NCX2.

规格	价格	库存
10 mg	￥680	In stock
25 mg	￥1180	In stock
50 mg	￥1980	In stock
100 mg	￥2980	In stock
250 mg		Get quote

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生物&药学活性

KB-R7943 (No.7943) is a selective inhibitor of Na+/Ca2+ exchanger (NCX), 3-fold more inhibitory to NCX3 than to NCX1 or NCX2.
KB-R7943 inhibits Na+i-dependent Ca2+ uptake and Na+i-dependent [Ca2+]i increase in cardiomyocytes, smooth muscle cells, and NCX1-transfected fibroblasts with IC50 of 1.2-2.4 uM.
KB-R7943 is much less potent in inhibiting Na+o-dependent Ca2+ efflux and Na+o-induced [Ca2+]i decline (IC50>30 uM).
KB-R7943 inhibited Na+i-dependent Ca2+ uptake and Na+o-dependent Ca2+ efflux in n cardiac sarcolemmal preparations with IC50 of 5.4-13 uM.
KB-R7943 markedly inhibited Ca2+ overloading into cardiomyocytes under the Ca2+ paradox conditions.

物理化学性质&存储条件

分子量	427.490
分子式	C17H21N3O6S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothiourea mesylate

参考文献

1. Iwamoto T, et al. J Biol Chem. 1996 Sep 13;271(37):22391-7.

2. Watano T, et al. Br J Pharmacol. 1996 Oct;119(3):555-63.

KB-R7943 (No.7943, KB-R7943 mesylate)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

KB-R7943 (No.7943, KB-R7943 mesylate)

生物&药学活性

物理化学性质&存储条件

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