KB-151 | Phagocytosis inhibitor | Probechem Biochemicals

Chemical Structure : KB-151

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KB-151 (KB151)

货号: PC-23439Not For Human Use, Lab Use Only.

KB-151 is a small molecule phagocytosis inhibitor with IC50 of 2.7 uM in human PBMCs, shows no significant toxicity.

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生物&药学活性

KB-151 is a small molecule phagocytosis inhibitor with IC50 of 2.7 uM in human PBMCs, shows no significant toxicity.
KB-151 is also able to inhibit phagocytosis in a murine system, albeit at a higher IC50 values.
KB-151 shows efficacy to ameliorate experimental ITP and AIHA, reverses ITP and/or AIHA, or cooperate with IVIG to increase efficacy.

物理化学性质&存储条件

分子量	457.29
分子式	C19H17BrN6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 4-(4-bromo-1-ethyl-1H-pyrazole-3-carboxamido)-5-cyano-1-phenyl-1H-pyrazole-3-carboxylate

参考文献

1. Loriamini M, et al. Small molecule drugs that inhibit phagocytosis. Molecules. 2023; 28(2): 757.

2. Loriamini M, et al. Transfusion. 2024 Nov 7. doi: 10.1111/trf.18060.

KB-151 (KB151)

生物&药学活性

物理化学性质&存储条件

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KB-151 (KB151)

生物&药学活性

物理化学性质&存储条件

参考文献

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