KB-141 |CAS:219691-94-8 Probechem Biochemicals

Chemical Structure : KB-141

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KB-141 (KB141)

货号: PC-35610Not For Human Use, Lab Use Only.

KB-141 (KB141) is a potent, selective thyroid hormone receptor TRβ (THR-β) agonist (IC50=1.1 nM), binds to hTRβ with a 14-fold higher affinity than to hTRα.

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生物&药学活性

KB-141 (KB141) is a potent, selective thyroid hormone receptor TRβ (THR-β) agonist (IC50=1.1 nM), binds to hTRβ with a 14-fold higher affinity than to hTRα.
KB-141 selectively reduces plasma cholesterol levels, also increases whole body oxygen consumption (MVO2) in both mice and rats.

物理化学性质&存储条件

分子量	355.21
分子式	C17H16Cl2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[3,5-dichloro-4-(4-hydroxy-3-propan-2-ylphenoxy)phenyl]acetic acid

参考文献

1. Grover GJ, et al. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):10067-72.

2. Johansson L, et al. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10297-302.

3. Grover GJ, et al. Cardiovasc Drug Rev. 2005 Summer;23(2):133-48. Review.

4. Ye L, et al. J Med Chem. 2003 Apr 24;46(9):1580-8.

KB-141 (KB141)

生物&药学活性

物理化学性质&存储条件

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KB-141 (KB141)

生物&药学活性

物理化学性质&存储条件

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