KB-0118 | BET bromodomain | Probechem Biochemicals

Chemical Structure : KB-0118

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KB-0118 (KB0118)

货号: PC-24237Not For Human Use, Lab Use Only.

KB-0118 is a selective BET bromodomain inhibitor with Kd of 36.7 uM for BRD2 BD1 and 47.4 uM for BRD4 BD1, shows immunomodulatory effects in inflammatory bowel disease (IBD).

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生物&药学活性

KB-0118 is a selective BET bromodomain inhibitor with Kd of 36.7 uM for BRD2 BD1 and 47.4 uM for BRD4 BD1, shows immunomodulatory effects in inflammatory bowel disease (IBD).
KB-0118 demonstrates selective binding to BRD2 and BRD4 over BRD3 in TR-FRET assays.
KB-0118 effectively inhibited pro-inflammatory cytokines, including TNF, IL-1β, and IL-23a, and selectively suppressed Th17 cell differentiation, a critical driver of IBD pathology.
KB-0118 significantly reduced disease severity, preserved colon structure, and lowered IL-17 expression in both DSS-induced and T cell-mediated colitis models.

物理化学性质&存储条件

分子量	309.28
分子式	C17H11NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3,5,7-trihydroxy-2-(1H-indol-6-yl)-4H-chromen-4-one

参考文献

1. Jeong YJ, et al. Biomed Pharmacother. 2025 Mar 14;185:117933.

KB-0118 (KB0118)

生物&药学活性

物理化学性质&存储条件

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KB-0118 (KB0118)

生物&药学活性

物理化学性质&存储条件

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