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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Tryptophan Hydroxylase (TPH)-KAR5585
KAR5585

Chemical Structure : KAR5585

CAS No.: 1673571-51-1

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KAR5585 (KAR-5585, Rodatristat ethyl)

货号: PC-62808Not For Human Use, Lab Use Only.

KAR5585 (Rodatristat ethyl) is the prodrug of the potent TPH1 inhibitor KAR5417, shows robust reduction of intestinal serotonin (5-HT) levels in mice.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

KAR5585 (Rodatristat ethyl) is the prodrug of the potent TPH1 inhibitor KAR5417, shows robust reduction of intestinal serotonin (5-HT) levels in mice.
KAR5585 generates high and sustained systemic exposure of the active parent KAR5417 in rats and dogs; orally bioavailable.

物理化学性质&存储条件

分子量 590.044
分子式 C29H31ClF3N5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

ethyl (S)-8-(2-amino-6-((R)-1-(5-chloro-[1,1'-biphenyl]-2-yl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylate

参考文献

1. Goldberg DR, et al. Bioorg Med Chem Lett. 2017 Feb 1;27(3):413-419.

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