KAN0438757 | PFKFB3 inhibitor | Probechem Biochemicals

Chemical Structure : KAN0438757

CAS No.: 1451255-59-6

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KAN0438757 (KAN 0438757, KAN-0438757)

货号: PC-35684Not For Human Use, Lab Use Only.

KAN0438757 (KAN-0438757) is a potent, selective PFKFB3 inhibitor, the ester prodrug of KAN0438241 with enhanced cell permeability.

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2380	In stock
25 mg	￥3980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

KAN0438757 (KAN-0438757) is a potent, selective PFKFB3 inhibitor, the ester prodrug of KAN0438241 with enhanced cell permeability.
KAN0438757 impairs recruitment of ribonucleotide reductase M2 and deoxynucleotide incorporation upon DNA repair, and reduces dNTP levels.
KAN0438757 selectively inhibits proliferation of transformed cells while sparing nontransformed cells.
KAN0438757 demonstrates significant suppression of intracellular F-2,6-P2 levels with sub µM IC50 values in cell lines representing pancreatic, gastric, and colon cancer (IC50=0.24 uM in Mia Paca-2 cells).

物理化学性质&存储条件

分子量	447.433
分子式	C21H18FNO7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-hydroxyethyl 4-((5'-fluoro-2'-hydroxy-[1,1'-biphenyl])-3-sulfonamido)-2-hydroxybenzoate

参考文献

1. Gustafsson NMS, et al. Nat Commun. 2018 Sep 24;9(1):3872.

KAN0438757 (KAN 0438757, KAN-0438757)

生物&药学活性

物理化学性质&存储条件

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KAN0438757 (KAN 0438757, KAN-0438757)

生物&药学活性

物理化学性质&存储条件

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