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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-Ras-KAL-21404358
KAL-21404358

Chemical Structure : KAL-21404358

CAS No.: 1065573-84-3

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KAL-21404358 (KAL21404358)

货号: PC-38329Not For Human Use, Lab Use Only.

KAL-21404358 (KAL21404358) is a small-molecule, allosteric inhibitor of K-Ras(G12D), binds to K-Ras(G12D) P110 site with KD of 88 uM in MST assay.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    KAL-21404358 (KAL21404358) is a small-molecule, allosteric inhibitor of K-Ras(G12D), binds to K-Ras(G12D) P110 site with KD of 88 uM in MST assay.
    KAL-21404358 disrupts the K-RasG12D-B-Raf interaction using a NanoBiT split luciferase assay, and to impair the Raf-MEK-ERK and the PI3K-AKT signaling pathways.
    KAL-21404358 exhibited specificity for K-RasG12D over K-RasWT, H-RasWT, Rap1a, R-Ras and R-Ras2.

    物理化学性质&存储条件

    分子量 357.498
    分子式 C21H31N3O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-((3-(2-hydroxyethyl)-4-neopentylpiperazin-1-yl)methyl)quinolin-4-ol

    参考文献

    1. Huizhong Feng, et al. Biochemistry. 2019 May 28;58(21):2542-2554.

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