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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-nAChR-KAB-18
KAB-18

Chemical Structure : KAB-18

CAS No.: 741678-60-4

KAB-18 (KAB18;KAB 18)

货号: PC-60678Not For Human Use, Lab Use Only.

A potent, selective, noncompetitive human α4β2 nAChRs negative allosteric modulator with IC50 of 13.5 uM, displays no inhibitory activity on Hα3β4 nAChRs at 100 uM..

规格 价格 库存 数量
25 mg Get quote
100 mg Get quote
250 mg Get quote
1 g Get quote

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

A potent, selective, noncompetitive human α4β2 nAChRs negative allosteric modulator with IC50 of 13.5 uM, displays no inhibitory activity on Hα3β4 nAChRs at 100 uM.

物理化学性质&存储条件

分子量 413.561
分子式 C28H31NO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(1-(3-phenylpropyl)piperidin-3-yl)methyl [1,1'-biphenyl]-2-carboxylate

参考文献

1. Henderson BJ, et al. J Pharmacol Exp Ther. 2010 Sep 1;334(3):761-74.

2. Pavlovicz RE, et al. PLoS One. 2011;6(9):e24949.

3. Henderson BJ, et al. ACS Chem Neurosci. 2012 Sep 19;3(9):682-92.

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