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首页-小分子抑制剂&激动剂-Epigenetics-HDAC-KA2507
KA2507

Chemical Structure : KA2507

CAS No.: 1636894-46-6

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KA2507 (KA-2507, KA 2507)

货号: PC-72342Not For Human Use, Lab Use Only.

KA2507 (KA-2507, KA 2507) is a potent and selective inhibitor of HDAC6 with IC50 of 2.5 nM, >300-fold selectivity over other HDACs.

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5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

KA2507 (KA-2507, KA 2507) is a potent and selective inhibitor of HDAC6 with IC50 of 2.5 nM, >300-fold selectivity over other HDACs.
KA2507 demonstrated cellular potency (IC50=150 nM) in a cellular assay measuring induction of acetylated α-tubulin, a marker of HDAC6 inhibition.
KA2507 displays antiproliferative effects against a set of 93 human cancer cells with IC50 of 2-30 uM.
KA2507 inhibits tumor growth in the syngeneic B16-F10 mouse melanoma model.

物理化学性质&存储条件

分子量 322.328
分子式 C16H14N6O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzamide, 4-[(di-2-pyrazinylamino)methyl]-N-hydroxy-

参考文献

1. Apostolia M Tsimberidou, et al. Clin Cancer Res. 2021 Jul 1;27(13):3584-3594.

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