K858 | Kinesin Eg5 inhibitor | Probechem Biochemicals

Chemical Structure : K858

CAS No.: 72926-24-0

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K858 (K-858, K 858)

货号: PC-45767Not For Human Use, Lab Use Only.

K858 is a potent, selective inhibitor of mitotic kinesin Eg5 ATPase activity with IC50 of 1.3 uM.

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10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥2180	In stock
100 mg	￥3680	In stock
250 mg		Get quote

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生物&药学活性

K858 is a potent, selective inhibitor of mitotic kinesin Eg5 ATPase activity with IC50 of 1.3 uM.
K858 displays >150-fold more selective for Eg5 than other members of the kinesin superfamily.
K858 induces mitotic arrest, apoptosis, and cell growth inhibition through the activation of the Mad2-mediated spindle checkpoint, and has no effect on microtubule polymerization.
K858 exhibits potent antitumor activity in xenograft models of cancer, and induces the accumulation of mitotic cells with monopolar spindles in tumor tissues.

物理化学性质&存储条件

分子量	277.3421
分子式	C13H15N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Acetamide, N-(4-acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)-

参考文献

1. Nakai R, et al. Cancer Res. 2009 May 1;69(9):3901-9.

2. De Iuliis F, et al. Invest New Drugs. 2016 Aug;34(4):399-406.

3. De Monte C, et al. Eur J Med Chem. 2015 Nov 13;105:245-62.

K858 (K-858, K 858)

生物&药学活性

物理化学性质&存储条件

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K858 (K-858, K 858)

生物&药学活性

物理化学性质&存储条件

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