K786-4469

Chemical Structure : K786-4469

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货号: PC-20482Not For Human Use, Lab Use Only.

K786-4469 is a small molecule inhibitor of anoctamin 1 (ANO1), suppresses cancer metastasis in vitro and in vivo.

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生物&药学活性

K786-4469 is a small molecule inhibitor of anoctamin 1 (ANO1, TMEM16A) channel, suppresses cancer metastasis in vitro and in vivo.
K786-4469 not only decreased ANO1 expression and increased expression levels of its downstream targets CYP27A1, ABCA1 and ABCG1 in a dose-dependent manner accordingly, but also reduced the intracellular cholesterol level in ESCC cells.
K786-4469 binds to ARG557 in ANO1 to repress cholesterol level and exert it's antimetastatic bioactivity through regulation of CYP27A1-LXR-ABCA1/ABCG1 axis.

物理化学性质&存储条件

分子量	614.76
分子式	C34H38N4O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(benzo[d][1,3]dioxol-5-ylmethyl)-1-cyclohexyl-2-(1-tosylpiperidin-4-yl)-1H-benzo[d]imidazole-5-carboxamide

参考文献

1. Deng CM, et al. Cancer Res. 2023 Mar 13:CAN-22-3490.

K786-4469

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物理化学性质&存储条件

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K786-4469

生物&药学活性

物理化学性质&存储条件

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