K303MP20 (MP20) | GPRC5B/C inhibitor | Probechem Biochemicals

Chemical Structure : K303MP20

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K303MP20 (Compound MP20)

货号: PC-27579Not For Human Use, Lab Use Only.

K303MP20 (MP20) is a small molecule inhibitor of orphan GPCR GPRC5B and GPRC5C dimerization, inhibits GPRC5B/C-mediated modulation of EP2, IP, and AT1 signaling in vitro and in vivo.

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生物&药学活性

K303MP20 (MP20) is a small molecule inhibitor of orphan GPCR GPRC5B and GPRC5C dimerization, inhibits GPRC5B/C-mediated modulation of EP2, IP, and AT1 signaling in vitro and in vivo.
MP20 inhibits GPRC5B/GPRC5C-mediated facilitation of EP2 signaling not only in HEK cells, but also in primary mouse and human macrophages.
MP20 reduces butaprost-induced cAMP production and facilitated migration in resident peritoneal macrophages (RPMs).
MP20 inhibits butaprost-induced cAMP production in human blood monocyte.
MP20 improves host defense both in bacterial peritonitis and influenza A virus infection.
MP20 reduces smooth muscle cells (SMCs) contractility and protects from arterial hypertension.

物理化学性质&存储条件

分子量	405.51
分子式	C22H27N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-((4-(3-methoxyphenyl)piperazin-1-yl)methyl)-N2-(m-tolyl)-1,3,5-triazine-2,4-diamine

参考文献

1. Kwon J, et al. J Clin Invest. 2026 Aug 3;136(15):e203162.

K303MP20 (Compound MP20)

生物&药学活性

物理化学性质&存储条件

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K303MP20 (Compound MP20)

生物&药学活性

物理化学性质&存储条件

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