K2P16-i7 (VU0544194)

Chemical Structure : K2P16-i7

加入收藏

货号: PC-27004Not For Human Use, Lab Use Only.

K2P16-i7 (VU0544194) is a potent, selective, reversible inhibitor of two-pore domain K+ (K2P) channel TALK-1 with IC50 of 5.2 uM, promotes β-cell function.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

K2P16-i7 (VU0544194) is a potent, selective, reversible inhibitor of two-pore domain K+ (K2P) channel TALK-1 with IC50 of 5.2 uM, promotes β-cell function.
K2P16-i7 does not affect other K+ channels (ie, TALK-2, TASK-3, KATP, and hERG).
K2P16-i7 inhibits TALK-1 channels localized to the ER membrane in addition to inhibiting Tl+ flux through TALK-1 channels in the plasma membrane.
K2P16-i7 inhibits primary β-cell TALK-1 currents and increases glucose-stimulated Ca2+ entry.
K2P16-i7 enhances insulin secretion from C57Bl/6J islets, promotes second-phase GSIS (glucose-stimulated insulin secretion).

物理化学性质&存储条件

分子量	339.35
分子式	C18H17N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 5-(3-methoxybenzamido)pyrazolo[1,5-a]pyridine-3-carboxylate

参考文献

1. Nakhe AY, et al. Mol Pharmacol. 2026 May 15;108(5-6):100130.