K284 (K284-6111) | CHI3L1 inhibitor | Probechem Biochemicals

Chemical Structure : K284

CAS No.: 702668-62-0

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K284 (CHI3L1 inhibitor K284, K284-6111)

货号: PC-47042Not For Human Use, Lab Use Only.

K284 (K284-6111) is a selective small molecule inhibitor of chitinase 3 like1 (CHI3L1) with strong binding affinity (Kd=-9.7 kcal·mol-1), inhibits lung metastasis by blocking IL-13Rα2-mediated JNK-AP-1 signals.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

K284 (K284-6111) is a selective small molecule inhibitor of chitinase 3 like1 (CHI3L1) with strong binding affinity (Kd=-9.7 kcal·mol-1), inhibits lung metastasis by blocking IL-13Rα2-mediated JNK-AP-1 signals.
K284 inhibits the growth of A549 (IC50=2.5 uM) and H460 cells (IC50=2.7 uM), arrests cell cycle, and induces apoptotic cell death.
K284 (0.5 mg/kg) inhibits B16F10 melanoma metastasis to the lungs in C57BL/6 mice.
K284 inhibits CHI3L1/IL‐13Rα2 signaling and JNK/AP‐1 signaling in A549 and H460 cell lines.

物理化学性质&存储条件

分子量	535.703
分子式	C30H37N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-({3-[2-(1-cyclohexen-1-yl)ethyl]-6,7-dimethoxy-4-oxo-3,4-dihydro-2-quinazolinyl}sulfanyl)-N-(4-ethylphenyl)butanamide

参考文献

1. Lee YS, et al. Mol Oncol. 2022 Jan;16(2):508-526.

K284 (CHI3L1 inhibitor K284, K284-6111)

生物&药学活性

物理化学性质&存储条件

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K284 (CHI3L1 inhibitor K284, K284-6111)

生物&药学活性

物理化学性质&存储条件

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