K02288 |CAS:1431985-92-0 Probechem Biochemicals

Chemical Structure : K02288

CAS No.: 1431985-92-0

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K02288 (K 02288;K-02288)

货号: PC-42940Not For Human Use, Lab Use Only.

K02288 is a potent, selective inhibitor of BMP signaling with IC50 of 1.8/1.1/34.4/6.3 nM for ALK/1/2/3/6, displays 300-fold selectivity for ALK2 over the TGF-β receptor ALK5 and ALK4.

规格	价格	库存
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

K02288 is a potent, selective inhibitor of BMP signaling with IC50 of 1.8/1.1/34.4/6.3 nM for ALK/1/2/3/6, displays 300-fold selectivity for ALK2 over the TGF-β receptor ALK5 and ALK4.
K02288 also wekaly inhibits type II BMP receptor ActRIIA (IC50=220 nM).
K02288 specifically inhibits the BMP-induced Smad pathway without affecting TGF-β signaling and induces dorsalization of zebrafish embryos.
K02288 inhibits BMP9-induced phosphorylation of SMAD1/5/8 in HUVECs to reduce both the SMAD and the Notch-dependent transcriptional responses, inhibits functional angiogenesis.

物理化学性质&存储条件

分子量	352.3838
分子式	C20H20N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 58.6 mg/mL
Chemical Name/SMILES	Phenol, 3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]-

参考文献

1. Sanvitale CE, et al. PLoS One. 2013 Apr 30;8(4):e62721.

2. Mohedas AH, et al. J Med Chem. 2014 Oct 9;57(19):7900-15.

3. Kerr G, et al. Angiogenesis. 2015 Apr;18(2):209-17.

4. Windhausen T, et al. Molecules. 2015 Apr 24;20(5):7586-601.

K02288 (K 02288;K-02288)

生物&药学活性

物理化学性质&存储条件

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K02288 (K 02288;K-02288)

生物&药学活性

物理化学性质&存储条件

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