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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-Ras-K-Ras G12C-IN-12
K-Ras G12C-IN-12

Chemical Structure : K-Ras G12C-IN-12

CAS No.: 1469337-95-8

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K-Ras G12C-IN-12

货号: PC-45536Not For Human Use, Lab Use Only.

An allosteric inhibitor of oncogenic K-Ras(G12C) with EC50 of 0.32 uM in H1792 cells.

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10 mg ￥1520 In stock
50 mg ￥6000 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

An allosteric inhibitor of oncogenic K-Ras(G12C) with EC50 of 0.32 uM in H1792 cells; relys on the mutant cysteine for binding and therefore do not affect the wild-type K-Ras.

物理化学性质&存储条件

分子量 449.6713
分子式 C15H17ClIN3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 48 mg/mL
Chemical Name/SMILES

2-Propen-1-one, 1-[4-[2-[(4-chloro-2-hydroxy-5-iodophenyl)amino]acetyl]-1-piperazinyl]-

参考文献

1. Ostrem JM, et al. Nature. 2013 Nov 28;503(7477):548-51.

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