K-756 | TNKS1/2 inhibitor | Probechem Biochemicals

Chemical Structure : K-756

CAS No.: 130017-40-2

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K-756 (K756)

货号: PC-23199Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3480	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

K-756 is a small molecule inhibitor of the Wnt/β-catenin pathway with IC50 of 110 nM in Wnt/β-catenin reporter assay, and selective tankyrase (TNKS) inhibitor with IC50 of 31 and 36 nM for TNKS1 and TNKS2, stabilizes Axin1/2 by inhibiting TNKS1/2.
K-756 binds to the induced pocket of TNKS and inhibits its enzyme activity.
K-756 inhibited the cell growth of APC-mutant colorectal cancer COLO 320DM and SW403 cells by inhibiting the Wnt/β-catenin pathway.
K-756 inhibited the Wnt/β-catenin pathway in colon cancer xenografts in mice.
When K-756 was combined with an EGFR inhibitor (gefitinib), it showed a strong synergistic effect.

物理化学性质&存储条件

分子量	433.51
分子式	C24H27N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((1-(6,7-Dimethoxyquinazolin-4-yl)piperidin-4-yl)methyl)-3,4-dihydroquinazolin-2(1H)-one

参考文献

1. Okada-Iwasaki R, et al. Mol Cancer Ther. 2016 Jul;15(7):1525-34.

K-756 (K756)

生物&药学活性

物理化学性质&存储条件

参考文献

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K-756 (K756)

生物&药学活性

物理化学性质&存储条件

参考文献

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