K-604 | ACAT-1 inhibitor | Probechem Biochemicals

Chemical Structure : K-604

CAS No.: 217094-32-1

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K-604 (K604)

货号: PC-62954Not For Human Use, Lab Use Only.

K-604 is a potent, selective and competitive ACAT-1 inhibitor with IC50 of 0.45 uM for human ACAT-1, displays 229-fold selectivity over ACAT-2.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3480	In stock
50 mg	￥5480	In stock
100 mg		Get quote

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生物&药学活性

K-604 is a potent, selective and competitive ACAT-1 inhibitor with IC50 of 0.45 uM for human ACAT-1, displays 229-fold selectivity over ACAT-2.
K-604 inhibits cholesterol esterification in human monocyte-derived macrophages with IC50 of 60 nM, enhances cholesterol efflux from THP-1 macrophages to HDL3 or apolipoprotein A-I.
K-604 suppresses the development of atherosclerosis in an animal model without affecting plasma cholesterol levels.

物理化学性质&存储条件

分子量	575.63
分子式	C23H32Cl2N6OS3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[2-(1H-Benzimidazol-2-ylthio)ethyl]-N-[6-methyl-2,4-bis(methylthio)-3-pyridinyl]-1-piperazineacetamide dihydrochloride

参考文献

1. Ikenoya M, et al. Atherosclerosis. 2007 Apr;191(2):290-7.

2. Shibuya Y, et al. J Neurosci. 2014 Oct 22;34(43):14484-501.

3. Yoshinaka Y, et al. Atherosclerosis. 2010 Nov;213(1):85-91.

K-604 (K604)

生物&药学活性

物理化学性质&存储条件

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K-604 (K604)

生物&药学活性

物理化学性质&存储条件

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