K-312 | CETP inhibitor | Probechem Biochemicals

Chemical Structure : K-312

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K-312 (K312)

货号: PC-63168Not For Human Use, Lab Use Only.

K-312 is a cholesteryl ester transfer protein (CETP) inhibitor with IC50 of 60 nM, also suppresses hepatocyte expression of PCSK9, raises HDL and lowers LDL cholesterol levels in vivo.

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生物&药学活性

K-312 is a cholesteryl ester transfer protein (CETP) inhibitor with IC50 of 60 nM, also suppresses hepatocyte expression of PCSK9, raises HDL and lowers LDL cholesterol levels in vivo.
K-312 raises HDL cholesterol, decreases LDL cholesterol, and attenuates aortic atherosclerosis in cholesterol-fed rabbits.
K-312 decreases PCSK9 expression in human primary hepatocytes and in the human hepatoma cell line HepG2, decreases the occupancy of SREBP-1 and SREBP-2 on the sterol regulatory element of the PCSK9 promoter.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Miyosawa K, et al. Am J Physiol Endocrinol Metab. 2015 Jul 15;309(2):E177-90.

2. Daniel Pettersen, et al. Small molecule modulators of PCSK9-a literature and patent overview. Bioorg Med Chem Lett. 2018 Feb 26. pii: S0960-894X(18)30151-3.

K-312 (K312)

生物&药学活性

物理化学性质&存储条件

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K-312 (K312)

生物&药学活性

物理化学性质&存储条件

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