Jun9-62-2R

Chemical Structure : Jun9-62-2R

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货号: PC-72516Not For Human Use, Lab Use Only.

Jun9-62-2R is a potent, selective, covalent SARS-CoV-2 Mpro inhibitor with IC50 of 0.43 uM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Jun9-62-2R is a potent, selective, covalent SARS-CoV-2 Mpro inhibitor with IC50 of 0.43 uM.
Jun9-62-2R is highly selective toward Mpro and does not inhibit the host calpain I, cathepsins B, K, L, caspase-3, and trypsin.
Jun9-62-2R inhibited SARS-CoV-2 viral replication with an EC50 of 2.05 μM in Caco2-hACE2 cells.
Jun9-62-2R forms a covalent adduct with the catalytic cysteine Cys145 of SARS-CoV-2 Mpro.

物理化学性质&存储条件

分子量	518.438
分子式	C29H25Cl2N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-([1,1'-biphenyl]-4-yl)-2,2-dichloro-N-((R)-2-oxo-2-(((S)-1-phenylethyl)amino)-1-(pyridin-3-yl)ethyl)acetamide

参考文献

1. Chunlong Ma, et al. J Am Chem Soc. 2021 Dec 15;143(49):20697-20709.

Jun9-62-2R

生物&药学活性

物理化学性质&存储条件

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Jun9-62-2R

生物&药学活性

物理化学性质&存储条件

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