Jun6504

Chemical Structure : Jun6504

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货号: PC-24874Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

Jun6504 is a specific small molecule inhibitor of Enterovirus D68 (EV-D68) viral 2C inhibitor, shows potent and broad-spectrum antiviral activity with EC50 of 0.25 uM in CPE assay with EV-D68 US/MO/14-18947 in RD cells.
Jun6504 exhibits potent antiviral activities against EV-A71 (EC50 = 0.27 to 0.61 µM) and CVB3 (EC50 = 0.18 to 2.03 µM).
Jun6504 displays broad-spectrum antiviral activity against enteroviruses with EC50 of 0.25 to 0.47 µM against five strains of EV-D68 isolated from the 2014 epidemic.
Jun6504 exhibits dose-dependent inhibition against CVA16, CVA6, poliovirus type 1, and CVB3 in CPE assay with EC50 values from 0.24 to 0.57 µM。
Jun6504 is not cytotoxic in Hela, RD, or Vero cells.
2C-D183V mutation is the predominant contributor to drug resistance, while mutations I112V and D323G confer resistance to a lesser extent.
Jun6504 (50 mg/kg, Vehicle: 90% corn oil + 10% DMSO) is effective at protecting mice from EV-D68 infection-induced paralysis, also reduces viral titers in the spinal cord and the infected quadriceps muscle.

物理化学性质&存储条件

分子量	327.43
分子式	C18H25N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-cyclopropyl-1-isopropyl-N-((3-methylazetidin-3-yl)methyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide

参考文献

1. Li K, et al. Nat Commun. 2025 Jul 1;16(1):5987.

Jun6504

生物&药学活性

物理化学性质&存储条件

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Jun6504

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