Jun12682

Chemical Structure : Jun12682

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货号: PC-23384Not For Human Use, Lab Use Only.

Jun12682 is a potent SARS-CoV-2 papain-like protease (PLpro) inhibitor with Ki/IC50 values of 37.7/106.8 nM.

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生物&药学活性

Jun12682 is a potent SARS-CoV-2 papain-like protease (PLpro) inhibitor with Ki/IC50 values of 37.7/106.8 nM.
Jun12682 inhibits the deubiquitinating and deISGylating activities of PLpro, which are crucial for antagonizing the host's innate immune response upon viral infection.
Jun12682 exhibits potent antiviral activity against SARS-CoV-2 and its variants, including nirmatrelvir-resistant mutants, in Caco-2 cells (EC50: 0.44–2.02 μmol/L).
Jun12682 oral administration significantly improved survival rates and alleviated both lung virus loads and histopathological lesions in a lethal SARS-CoV-2 mouse model.

物理化学性质&存储条件

分子量	500.65
分子式	C29H36N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-5-(2-(dimethylamino)ethoxy)-N-(1-(3-(1-ethyl-1H-pyrazol-3-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenyl)ethyl)-2-methylbenzamide

参考文献

1. Mianling Yang, et al. Acta Pharm Sin B. 2024 Sep;14(9):4189-4192.

Jun12682

生物&药学活性

物理化学性质&存储条件

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Jun12682

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