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Juglone

Chemical Structure : Juglone

CAS No.: 481-39-0

Juglone (5-hydroxynaphthalene-1,4-dione, 5HN)

货号: PC-61683Not For Human Use, Lab Use Only.

Juglone (5-HN) is a plant-derived 1,4-naphthoquinone with confirmed antibacterial and antitumor activities.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Juglone (5-HN) is a plant-derived 1,4-naphthoquinone with confirmed antibacterial and antitumor activities.
Juglone inhibits the S. aureus bacterial tricarboxylic acid cycle (TCA cycle), as well as DNA and RNA synthesis, thus leading to cell collapse.
Juglone induces apoptosis of tumor stem-like cells through ROS-p38 pathway in glioblastoma in vitro and in vivo.
Juglone also reactivates latent HIV-1 through ROS and NF-kappaB without inducing global T cell activation.

物理化学性质&存储条件

分子量 174.16
分子式 C10H6O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-hydroxynaphthalene-1,4-dione

参考文献

1. Wang J, et al. Nat Prod Commun. 2016 Jun;11(6):825-7.

2. Yang HC, et al. J Clin Invest. 2009 Nov;119(11):3473-86.

3. Wu J, et al. BMC Neurol. 2017 Apr 7;17(1):70.

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