Jervine | Smo antagonist, Hh inhibitor | Probechem Biochemicals

Chemical Structure : Jervine

CAS No.: 469-59-0

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Jervine (11-Ketocyclopamine)

货号: PC-26424Not For Human Use, Lab Use Only.

Jervine is a steroid alkaloid Smoothened receptor (Smo) antagonist, inhibits Hh signaling pathway with IC50 of 500-700 nM, also is a dual-targeting kinase inhibitor of AURKB and CDK1.

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10 mg	￥980	In stock
25 mg	￥1580	In stock
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生物&药学活性

Jervine is a steroid alkaloid Smoothened receptor (Smo) antagonist, inhibits Hh signaling pathway with IC50 of 500-700 nM, also is a dual-targeting kinase inhibitor of AURKB and CDK1.

物理化学性质&存储条件

分子量	425.61
分子式	C27H39NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2'R,3S,3'R,3a'S,6aS,6bS,6'S,7a'R,11aS,11bR)-3-Hydroxy-3',6',10,11b-tetramethyl-1,3,3a',4,4',5',6,6a,6b,6',7,7',7a',8,11a,11b-hexadecahydro-3'H-spiro[benzo[a]fluorene-9,2'-furo[3,2-b]pyridin]-11(2H)-one

参考文献

1. Wilson CW, et al. PLoS One. 2009;4(4):e5182.

2. Sulaimani MN, et al. Front Pharmacol. 2025 Nov 21;16:1662556.

3. Williams JA, et al. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4616-21.

4. Cooper M K, et al. Science. 1998;280:1603–1607.

Jervine (11-Ketocyclopamine)

生物&药学活性

物理化学性质&存储条件

参考文献

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Jervine (11-Ketocyclopamine)

生物&药学活性

物理化学性质&存储条件

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